Curr Opin Ophthalmol 18:398–401. ß 2007 Lippincott Williams & Wilkins.
Francesco P. Bernardini and Mario Bazzan
Lymphoproliferative tumors of the ocular adnexa encompass a wide spectrum of lesions that range from reactive benign hyperplasia to malignant lymphoma and a correct diagnosis is based on morphologic appearance, immunohistochemical features, flow cytometry and molecular genetic analysis using polymerase chain reaction.
The vast majority of lymphoproliferative lesions in this area are represented by the non- Hodgkin lymphoma (NHL) group, 80% of which arises from B-lymphocytes, 14% from T cells and only 6% from natural killer cells .
The most common primary ocular adnexal lymphoma(OAL) is the low-grade malignant extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) . Secondary OALs arise from systemic disease and are represented by intermediate or highgrade
follicular lymphomas [3,4].